Posted May 24th, 2018 by Liz Do

Inspired by art, engineering researchers use sound and visuals to simulate blood-flow patterns of brain aneurysms

A computer simulation of blood-flow patterns within an aneurysm, created by Professor David Steinman’s Biomedical Simulation Laboratory.

A computer simulation of blood-flow patterns within an aneurysm, created by Professor David Steinman’s Biomedical Simulation Laboratory.

U of T Engineering researchers are combining audio and art to provide better, standardized ways of simulating and understanding medical imaging of brain aneurysms.

Currently, if a patient comes into a medical clinic with an unruptured brain aneurysm, a clinician’s decision to operate or leave it depends on risk factors related to the patient’s medical history, as well as the aneurysm’s shape, size and location in the brain.

Aneurysms in the back of the brain, for example, are more likely to rupture than those at the front. “This is what the epidemiology has told us,” explains Professor David Steinman (MIE). However, many large aneurysms don’t ever rupture, and many small aneurysms that are normally left alone, do rupture.

So the question is: how does one treat only the aneurysms that are risky?

Steinman’s approach to finding a solution is a unique one — he’s melding biomedical engineering and the art world. Collaborating with Toronto Western Hospital’s Aneurysm Clinic, (Canada’s largest), as well as Peter Coppin, a professor at the Faculty of Design at OCADU, his lab is taking fresh insights from visual artists and sound designers to improve visual and audio communication in medical imaging, starting with aneurysms.

“Visualizations of computational fluid dynamics (CFD) are typically presented to clinicians as ‘canned’ animations, which tend to rely on dense engineering representations that unselectively portray both relevant and irrelevant details,” said Steinman.

By using graphics and sound to amplify key features, while suppressing irrelevant information, “This would allow a user to visually concentrate on one field, while listening to the other. Certain aspects of complexity can be heard better than it can be seen,” he said. A clinician can then more easily and efficiently decide whether to operate on an aneurysm.

If the simulated blood flow of the aneurysm were to show a very strong and unstable ‘jet’ coming into the aneurysm and against the aneurysm wall, “that might be a hint that that wall is more likely to be aggravated,” explains Steinman.

He hopes this innovative approach can help reduce the number of unnecessary treatments and the number of accidental ruptures. “Imagine I’m a patient with what I feel is a ticking time bomb in my head. What do I do about it? And a clinician tells me, ‘Well, we’re not sure,’” said Steinman. “I want to provide more information for the clinician. It’s a new piece of the puzzle to give to them.”

To work alongside Coppin’s team at OCADU, he has recruited MIE post-doctoral fellow Thangam Natarajan to translate CFD visually, and MIE MASc student Dan MacDonald to translate CFD into sounds.

MacDonald is a trained classical pianist, a skill that has helped elevate his project. “Piano led me to synthesizers and sound design,” he said. “So taking the data and turning them into sound, has a lot to do with knowing fundamentally how to create sound from the bottom up.”

The power of this approach can be seen and heard in this video:

In future, Steinman hopes his work will lead to a standardized, new way of representing and understanding how to treat aneurysms in medical clinics. “The way I see it, you’d build a tool where the CFD data could be displayed on a simple interface. Then, you’d either put on headphones or turn on the speakers, just like a Doppler ultrasound exam. We’re maybe five years away from that.”