Professor Milica Radisic (BME, ChemE) has been elected a fellow of the Canadian Academy of Health Sciences (CAHS), one of Canada’s three national academies. The CAHS leverages the expertise of Canada’s leading health sciences researchers to evaluate our most urgent and complex health challenges and recommend solutions. To be named a CAHS Fellow is considered one of the highest distinctions for academics in the health sciences in Canada.
Radisic is the Canada Research Chair in Organ-on-a-Chip Engineering and a senior scientist at the Toronto General Hospital Research Institute. She is also director of the NSERC CREATE Training Program in Organ-on-a-Chip Engineering & Entrepreneurship and a co-founder of the Centre for Research and Applications in Fluidic Technologies.
Radisic is internationally recognized for spearheading the field of organ-on-a-chip engineering and pioneering new tissue vascularization approaches. She invented methods to grow and mature contractile heart tissues starting from human stem cells, providing platforms for developing and studying human tissues and organs. This heart-on-a-chip technology is key to enabling a paradigm switch from “one-size fits all” drug discovery and testing in animals, towards precise and tailored discovery and testing in human tissues.
To commercially translate this technology, Radisic co-founded TARA Biosystems with her students. The company grew to more than 20 employees before its acquisition by Valo Health in 2022. At Valo, Radisic’s IP is the engine for AI-powered drug discovery, where AI-designed drugs are tested and validated in human cardiac tissue. A second start-up, Quthero, was formed to commercialize unique regenerative peptide materials developed in her lab.
Already a fellow of the Royal Society of Canada and the Canadian Academy of Engineering, Radisic is one of only a handful of scholars to be elected to all three of Canada’s national academies. She is also a fellow of the American Institute of Medical and Biological Engineering, the Tissue Engineering and Regenerative Medicine International Society, the American Association for the Advancement of Science, and the U.S. National Academy of Inventors.
In 2024, Radisic garnered the NSERC John C. Polanyi Award, for a recent outstanding scientific advance. Earlier this year she received a Governor General’s Innovation Award.
“Milica Radisic’s election to this prestigious institution, which makes her a member of all three of Canada’s national academies, demonstrates the incredible impact of her heart-on-a-chip technology across the fields of medicine and engineering,” says U of T Engineering Dean Christopher Yip.
“On behalf of the faculty, I congratulate her on this well-deserved honour.”
When Kelvin Cui (EngSci 2T2) launched Peripheral Labs, a computer vision startup, he knew he needed to build a team with a very specific mindset — and he knew just where to find that.
“During my undergrad, I was part of the U of T Formula Racing Team, and also aUToronto, which is our self-driving car team,” says Cui.
“There’s no out-of-the-box solution for any of the problems we needed to solve, and the competition is fierce. You need to be scrappy, to work fast, and to be able to take the theory that you learn in class and apply it to the actual challenges in front of you. The ambition, drive and competitive mentality that gets nurtured in those teams is what I wanted for my company.”
Though the seeds of Peripheral were planted while Cui was living in San Francisco and working at an acceleration program called Entrepreneurs First, he knew that Toronto was where he really wanted to be.
“The brain drain is real — if you walk around San Francisco, you run into so many people from Canada, and from Toronto in particular,” he says.
“I recognize the talent that there is at U of T. I thought that if we could offer the pay and experience that you could get with a startup in San Francisco, but enable people to stay here where the cost of living isn’t quite as high, we could hire the talent we need to create a really competitive, research-based company.”
After talking to some of his former teammates from U of T Formula Racing, he heard about the U of T Engineering Partnerships Office, the Faculty’s new co-location space at 800 Bay Street. The space is located adjacent to U of T’s St. George campus, in the heart of downtown Toronto. Cui and his team moved into that space in March 2025.
“Not only are we plugged into the talent pipeline, but we can also partner with the university to design new ways of testing our software, and we can consult with all kinds of experts in virtually any field,” he says.
“It’s been great.”
Peripheral is one of seven partner organizations that are currently co-located at the U of T Engineering Partnerships Office, thereby embedding themselves within a community of companies, researchers and entrepreneurs.
Co-located partners benefit from amenities, resources and convenience while tapping into an ecosystem that fosters rich collaboration. In addition to partner companies, the space is also home to AGE-WELL, a unique Canadian network dedicated to developing technologies and services for healthy aging.
“In creating this space, we were inspired by the Fujitsu Co-Creation Laboratory, which has been around for the better part of a decade now,” says Adriano Vissa, Executive Director, Partnerships at U of T Engineering.
“They license space in the Myhal Centre here on campus, and as a result, are able to work very closely with a wide range of experts across U of T. Over the years, this has led them to expand the number of professors they are working with and evolve the focus of their research program to meet the needs of their industry.
“It’s a really great example of what long-term, sustainable partnerships can do, so we wanted to explore ways to scale that up.”
The Engineering Partnerships Office includes private office space for co-located companies, lounge spaces, meeting rooms and a large bookable event hall. Partners pay a monthly fee that includes access to all the facilities. A compete description of what is available can be found on the U of T Engineering Partnerships website.
Vissa says that what he finds most rewarding is when the new proximity sparks unexpected collaborations.
“Earlier this year, we had a reception in the event space for the GenAI Collective, Toronto Chapter, which connects innovators in AI through in-person gatherings,” says Vissa.
“The CEO of one of our co-located partner companies was in the office that day, and mingled with the student attendees. He was so impressed that he came out to chat with some of them; I don’t know if any of them got hired, but it’s a good example of how putting talented people together in a room can lead to new ideas and new ventures.”
For Anastasia Polulyakhova (Year 3 MechE) and Katie Hung (Year 3 ChemE), this summer has been a whirlwind of hands-on learning as interns dedicated to Project Leap, the University of Toronto’s ambitious plan to reduce greenhouse gas (GHG) emissions by over 50 per cent by the end of 2027.
Polulyakhova’s focus has been lighting, supporting work to upgrade to energy efficient LEDs in 38 buildings across campus. She has been digging deep into the numbers to track, summarize and analyze energy savings data made possible by the upgrades.
“I’ve learned a lot about excel,” she laughs.
Hung has become a fixture in the construction zone currently surrounding the Medical Sciences Building, where crews are hard at work connecting key buildings to Canada’s largest urban geoexchange system under Front Campus. Her role has included site supervision, personal protective equipment monitoring and communicating with contractors about scheduling, issues management and more.
Both have found the experience invaluable, and have enjoyed the exposure to so many experienced professionals across a variety of trades and disciplines, including pipe fitters, welders, installers, heat tracers and energy managers with the St. George Sustainability Office.
“It’s awesome to hear people geek out about their work,” says Anastasia.
The real-world experience has been illuminating, with principles learned in class appearing in their work.
“It’s like all these puzzle pieces coming together,” says Katie, “what we’ve learned in class and what we’ve learned in real life.”
With their help, the first big step in the university’s vision to make the St. George campus climate positive by 2050 is coming to life. Through campus-wide sustainability solutions, including transforming how we heat and cool our campus, Project Leap will save nearly 50,000 metric tonnes of GHG emissions annually — equivalent to the energy use of more than 10,000 homes.
And while their summer internships with Ecosystem, one of the construction partners supporting Project Leap, may be coming to an end, Katie and Anastasia have a busy year of clubs, work and school ahead of them. With a few weeks left to go, they’re enthusiastic about learning as much as they can, and enjoying the generosity of spirit they’ve experienced on site.
You can learn more about Project Leap here.
Researchers at the University of Toronto, Brigham and Women’s Hospital, and Harvard Medical School have developed a swallowable, low-cost device that changes colour in the presence of inflammation in the gut.
Designed for people with inflammatory bowel diseases (IBD), such as Crohn’s disease or ulcerative colitis, the PRIM pill (Pill for ROS-responsive Inflammation Monitoring) could offer an easy, at-home alternative to current monitoring tools such as colonoscopies or lab-analyzed stool samples. With further development, this technology could help doctors and patients detect flare-ups earlier and adjust treatments more effectively.
This study was published in Device, a journal by Cell Press. The work is being co-led by Professor Caitlin Maikawa at the Institute of Biomedical Engineering at the University of Toronto, along with Professors Yuhan Lee and Jeffrey Karp, both at Harvard Medical School and Brigham and Women’s Hospital.
IBD affects more than seven million people worldwide and is often marked by unpredictable episodes of inflammation in the digestive tract. While long-term management depends on keeping inflammation under control, current methods for monitoring gut health are either invasive, expensive or underused. Colonoscopies remain the gold standard but are not practical for frequent use. Stool-based tests are less invasive, but many patients are unwilling to collect or send in samples, which limits long-term tracking.
“There’s a clear need for a tool that can make routine inflammation monitoring easier and more accessible for patients,” says Maikawa, co-corresponding author of the study.
“Our goal was to design something simple, affordable and patient-friendly that makes it possible to detect inflammation without needing a lab.”
The PRIM device uses a chemical marker called reactive oxygen species (ROS), which increases in the intestines during inflammation. The pill is coated with a specially designed polymer that remains intact in healthy conditions but breaks down when ROS levels are high. When this occurs, the pill releases a harmless blue dye. If inflammation is present, the dye colours the stool and toilet water blue, providing a clear visual signal that can be observed at home without handling stool or using specialized equipment.
The team tested the device in rats with induced gut inflammation and found that the pill detected inflammation with approximately 78 percent accuracy. Because the materials used to make the device are inexpensive, researchers estimate it could cost less than 50 cents to manufacture at scale. The simplicity of the design makes it more accessible to a broader population, including those in lower-resource settings.
The team continues to work on refining the pill design to bring the technology closer to clinical use. Lucia Huang, co-lead author on the study and an MSc student on Maikawa’s team, is working on new polymer materials that will more sensitively detect inflammatory markers like ROS. Future studies will also test the device in larger animal models that better mimic humans.
“We are working on refining the pill design, including improving the pill’s accuracy and exploring how our pill could interface with digital health technologies,” says Maikawa.
“Our long-term aim is to make regular inflammation monitoring as easy as possible.”
A new numerical modelling tool could help improve the design and operation of intermittent water distribution systems, which supply more than a billion people around the world.
“Water distribution networks are critical infrastructure, but they are also big, expensive and buried underground,” says Omar Abdelazeem (CivMin PhD student), lead author on a new study published in Water Resources Research.
“If you want to make a change to a system like that, you can’t just try it out and see what happens. You need a computer model that can accurately predict how your changes might affect the system. That way, you can test out many different possible improvements before you start the difficult and expensive process of implementing them.”
While there are plenty of commercial models designed for water distribution networks, they all make one important assumption: once the system is turned on, it stays on 24/7. But for about 20% of customers worldwide, that’s just not the case.
“In many places around the world, due to water scarcity or other factors, water is supplied for only a few hours per day,” says Professor David Meyer (CivMin), senior author of the new paper.
“Over a billion people get their water this way. And yet these systems are almost universally designed and updated using hydraulic models that assume continuous water supply. That means they don’t account for the pipes draining and refilling, and they don’t account for the fact that customers store water in large tanks in their homes so they can have it for later use.”
Meyer and his team have done many previous studies on intermittent water systems. This includes a comprehensive review of previous attempts to build models for them, which earned them the 2025 Medal for Reproduceable Research from the Journal of Water Resources Planning and Management.
Many of the examples they found in that work ultimately derived from a single source: the Storm Water Management Model (SWMM), an open-source model which was originally created by the United States Environmental Protection Agency (EPA) more than 50 years ago.
“That model was meant for stormwater, but with a little bit of work, you can adapt it for an intermittent water system that fills up and drains regularly,” says Abdelazeem.
“The problem is that different people disagreed about which parts of the model to use for what purposes. And these differences matter — we found that sometimes, values predicted by one model were thousands of times bigger or smaller than those from another.
“On top of that, many of the models were not reproduceable, meaning that even after reading the paper, you couldn’t glean enough information to build your own version.”
Building on this previous work, Abdelazeem and Meyer decided to create a new, ready-to-use model, with a Python package that enables users to implement it automatically. Dubbed SWMM for Intermittent Networks, or SWMMIN, the open-source model is available for free on GitHub.
“Our paper describes in detail how to use the model for various types of intermittent systems, and how to set up the numerical parameters to improve model performance,” says Abdelazeem.
“In addition to synthesizing the best practices from all the previous models, we also found an ideal ratio of spatial and temporal resolutions that minimizes model error.”
The team hopes that it will be used by researchers and water system operators alike to test out potential improvements to intermittent water systems all over the world.
“Ultimately, this is an attempt to model these water systems as they actually exist, rather than how we wish they existed,” says Meyer.
“We hope that people will use it to find new design principles, and that those in turn improve service for all the people who depend on these intermittent systems every day.”
Professor Bertrand Neyhouse joined the Department of Chemical Engineering & Applied Chemistry (ChemE) at the University of Toronto in June 2025.
His research group applies fundamental chemical and electrochemical engineering principles to design and scale up electrosynthetic processes — with the goal of deploying electrochemistry to discover innovative, sustainable methods for converting a wide range of feedstocks into valuable chemical products.
Originally from Ohio, Neyhouse earned his undergraduate degree in chemical engineering at Ohio University, not to be confused with Ohio State. Drawn by his love of math and chemistry, he chose chemical engineering without fully knowing what it entailed — but quickly discovered its complexity and breadth. His growing curiosity led him to pursue a PhD at MIT, where he specialized in electrochemical engineering, followed by postdoctoral research at the University of Michigan to deepen and diversify his expertise.
We spoke with Neyhouse about his path to U of T, the challenges he hopes to tackle, and his approach to teaching and life beyond the lab.
What initially sparked your interest in electrochemical engineering?
I actually tripped and fell into electrochemical engineering as a first-year undergraduate. Research sounded interesting, so on a whim, I reached out to the Center for Electrochemical Engineering Research and ended up interviewing the next day.
From there, I had the chance to conduct undergraduate research spanning wastewater treatment, microbial sensors and carbon dioxide conversion. My mentors, Gerri Botte and Travis White, really inspired me — they showed me just how versatile, applied and fascinating this field can be.
How have your past experiences shaped your career path?
Growing up, I always thought I’d want to be a teacher. But when I started applying to universities, I leaned toward engineering to apply my love for math and chemistry to real-world technical challenges. You can imagine my excitement when I got to Ohio University and realized professors get to do both: teach and lead research.
I was fortunate to have instructors who were deeply passionate about chemical engineering education, setting examples I’ve aspired to follow ever since. That inspiration has guided me in pursuing this path and in my commitment to guiding the next generation of chemical engineers.
What drew you to U of T?
Beyond U of T’s reputation for high-impact research, I was especially drawn to the department’s strong commitment to sustainability. Even more compelling is how we tackle complex global challenges from a truly diverse range of perspectives — from microbiology and biochemical engineering to electrochemistry, catalysis and environmental science.
The collaborative research culture really stood out to me as well: it provides a strong foundation for combining expertise across disciplines to develop practical solutions to big sustainability problems.
Are there specific challenges in your field that you’re eager to address?
Absolutely! Right now, there’s an explosion of interest in electrochemistry, and researchers are exploring a wide range of new chemical transformations. But many of these leading-edge developments are only tested at small batch scales, so we don’t know enough about how viable they’d be for industry.
My work aims to bridge these gaps by applying fundamental electrochemical engineering principles to design scalable chemical manufacturing pathways — ultimately leading to generalizable knowledge that supports process innovation.
How do you see your research contributing to the department’s broader goals?
My research is closely tied to sustainability and will help expand the department’s focus on cleaner chemical manufacturing, waste valorization and energy storage.
Ultimately, I hope my work contributes to building a more sustainable future by reducing environmental impact, conserving natural resources and slowing the progression of climate change.
How do you approach teaching, and what strategies do you use to engage students?
I want students to see the potential application behind every problem they approach. Chemical engineering fundamentals can sometimes feel abstract or aimless, but grounding them in real-world contexts helps give students focus and purpose.
I also like to give students space to discuss new ideas and example problems together before we work through them as a class. That reflection helps them identify what they understand — and where they might need to dig deeper — rather than just listening passively to a flow of information.
In terms of bringing research into the classroom, electrochemical technologies are really just specialized applications of chemical engineering; meaning there are rich examples that can be readily applied throughout the traditional chemical engineering curriculum.
What do you enjoy outside of work?
I’m typically up for anything — which means I have found myself with a lot of hobbies! I like to spend my free time hanging out with family and friends, hiking, camping, cycling, cooking, playing video and board games, watching and playing sports, exploring Toronto and traveling.
How do you balance your professional life with your personal interests?
I recognize and value the importance of balance in maintaining both a strong professional drive and a fulfilling personal life, so I’m intentional about setting aside time for family, friends and hobbies. It also helps that chemical engineering itself is a personal passion — when you love what you do, it often doesn’t feel like work!
Do any of your hobbies inspire your work?
Definitely. My passion for sustainability is closely tied to my love of nature — hiking, camping, cycling and traveling all remind me of what’s at stake. To protect the beautiful world (and country) we call home, we must find innovative ways to leverage resources and preserve our environment. This motivates me to keep pushing for cleaner, more sustainable technologies.