Often singled out for his academic leadership and research, U of T Professor Paul Santerre is being celebrated for a different reason this month. His leadership in moving his biomaterials discovery, Surface Modifying Macromolecules, to the marketplace has garnered him top prize from the 2014 Ernest C. Manning Innovation Awards.
The awards recognize Canadian innovators who have successfully created and marketed new concepts, processes or procedures. Santerre, from the Faculty of Dentistry and the Institute of Biomaterials & Biomedical Engineering (IBBME) (which spans the faculties of Applied Science & Engineering, Medicine and Dentistry), has been distinguished by this year’s $100K Principal Award.
Santerre’s discovery solves an important dilemma in medical care. When patients are fitted with tubing devices – used for everything from kidney dialysis to blood transfusions – the tubes can cause thrombosis (blood clots) to form. These clots can detach and lead to major complications or mortality. Current treatments involve coating devices with anti-coagulant drugs, such as heparin, that can strip away from the tubing and enter the body.
Rather than acting like a coating, Surface Modifying Macromolecules (referred by the trade name Endexo™) are added during manufacturing so that they are embedded throughout the device. The molecules don’t shed, and their success rate at preventing blood clots has been extremely high – reducing incidents of clots by as much as 87 per cent in blood loop tests, a lab test that simulates blood circulation in the body.
Santerre, who also won the NSERC Synergy Awards for Innovation for his research leadership in 2012, commercialized the intellectual property into a budding startup company, Interface Biologics, Inc., which then developed the molecular technology into several products. Garnering major investments, and then entering into licensing agreements with a leading U.S.-based biomedical device company, AngioDynamics, the company was able to develop the technology to a point that made it market-ready.
In the past two years the technology has jumped several major regulatory hurdles, including two approvals from the U.S. Food and Drug Administration (FDA), as well as similar approvals in Europe and Canada, and has quickly overtaken the market with strong interest. Within its first year of sales, Peripherially Inserted Central Catheters (PICC) containing Endexo landed 45 per cent in the Canadian market alone – and with new licensing partners, is set to steal a major piece of the dialysis market in the U.S., worth an estimated $2 billion.
Daniel Haas, Dean of the Faculty of Dentistry, dubbed Santerre’s latest tribute “fitting”: “Throughout his career here at the University of Toronto’s Faculty of Dentistry, as well as at IBBME, Paul has consistently demonstrated outstanding innovation in the field of biomaterials research that has brought him international recognition.”
The award recognizes Santerre as one of Canada’s leading inventors who has overcome the challenges associated with pushing his creation into the marketplace, and in turn, is helping to position Canada as a global leader in technology, business, engineering and social innovation.
It’s a job, Santerre admits, that’s not always easy.
“The Manning award is a recognition that the University of Toronto is driving and enabling the world class research of its academics to be translated into unique and transformative technologies for the health care field,” said Santerre, who urges decision-makers at all levels of government to “capitalize on the potential economic opportunities that exists in Canada,” especially those available through university research networks.
“Paul Santerre is a trailblazer in biomaterials and biomedical engineering,” said Cristina Amon, dean of the Faculty of Applied Science & Engineering. “Not only is he pioneering innovative research, but he is also transferring his findings directly to market so they can improve health care for people around the world. I extend my heartfelt congratulations on behalf of the Faculty for this richly-deserved award.”
“Paul Santerre is a talented and innovative research leader. The success of Interface Biologics is yet another example of how U of T-born research can lead to new clinical applications and economic success. I congratulate him on earning a Manning Award,” said Catharine Whiteside, Dean of the Faculty of Medicine and Vice Provost, Relations with Health Care Institutions.
Transforming intellectual property into booming businesses has become something of a trademark for the University of Toronto in recent years. The University consistently tops the rankings of North American schools for startup activity, according to research conducted by the Association of University Technology Managers (AUTM).
Read the full story on this year’s Manning Innovation Awards in Maclean’s magazine.
Most of us think of a classroom as rows of desks facing a podium or screen; students sit quietly, alternating between taking notes and listening to a professor lecture.
This is a model that all of us have experienced—but is it the best way to learn?
Eager to explore this question, U of T Engineering recently unveiled a pilot Technology Enhanced Active Learning (TEAL) classroom. TEAL rooms offer an innovative new educational method that facilitates collaboration and hands-on learning, assisted by technology and strategic design.
With several TEAL rooms expected in the forthcoming Centre for Engineering Innovation and Entrepreneurship (CEIE), the pilot project gives U of T engineering students and educators a taste of how the different format works
“The pilot room is a great chance for us to see the design in action,” said Steve Miszuk, director, facilities and infrastructure planning. “We can try out different layouts and technologies, get feedback and see what really works.”
Located in the Sandford Fleming building, the TEAL room features bright green chairs clustered around 12 hexagonal tables that are spread throughout the room. This layout – an alternative to the traditional lecture-style of all tables and chairs facing one podium – encourages collaboration amongst students. And thanks to wheels on all chairs and tables, the room can be as flexible as needed, quickly adjusting for exam or tutorial formats.
“The new TEAL classrooms provide a great space for collaborative learning in tutorials or courses with small class sizes,” said Susan McCahan, vice dean, undergraduate. “There’s a lot of evidence to suggest that active, team-based learning is an effective model for students, and this is a great chance to implement those practices.”
In addition to changing the method of how students learn and retain information, TEAL rooms also invite instructors to rethink how they deliver material. Rather than remaining stationary near the front of the room, professors
are encouraged to move from table to table.
Eight 80-inch screens are spaced evenly around the room – two on each wall – to make material visually accessible to every student. And with tables set at bar-height, the instructor is able to engage students at eye-level rather
than leaning down or lecturing from above.
To further enhance the collaborative experience and enable peer-to-peer learning, every table is equipped with ports so that students can showcase their work easily on the digital displays.
U of T Engineering’s pilot TEAL classroom is already being heavily used, with over 35 hours booked per week across a number of departments and divisions.
“The TEAL rooms are one example of collaborative learning spaces we’re implementing around campus,” said Miszuk, who also mentioned new study areas in the Bahen Centre. “Keep an eye out for more projects in the future.”
The Engineering alumni behind a wearable device called the “Nymi” – a bracelet-style product that uses your unique heart rhythm as a password to unlock or active devices – secured $14 million in investment this week from key industry players including Ignition Partners, Relay Ventures and MasterCard.
Developers Foteini Agrafioti (ElecE MASc 0T9, PhD 1T1) and Karl Martin (ElecE 0T1, MASc 0T3, PhD 1T0) created the technology as a research project while studying at U of T Engineering; commercializing it through a startup they called Bionym.
The “Nymi” detects and distinguishes a person’s unique heartbeat (cardiac signal) through built-in sensors. It can be used to secure various devices with an accuracy greater than 99%, roughly the same as current fingerprint-enabled security systems.
“[Bionym’s] at the forefront of a revolution in identity-based interactions with devices and services and our momentum continues to grow,” said Martin, the startup’s CEO. “This round of financing is providing us with the resources needed to bring the platform to market.”
To understand how the “Nymi” went from idea to finished product, U of T News’ Brianna Goldberg spoke with Jesse Rodgers, director of the Creative Destruction Lab program at the Rotman School of Management, and Kurtis Scissons, entrepreneurship manager at U of T’s Innovations & Partnerships Office (IPO) and co-director of the UTEST accelerator for early-stage software companies. Through their roles on campus, both contributed to the startup’s significant success.
What qualities of promise did you see in Bionym in the early days when they worked with you?
Scissons: Obviously they have a very interesting technology but more so it was the great balance of technical skill with business drive within the founding team. Coachability was a key personality trait for Karl and his co-founder, who both listened, respected and appreciated when others took time to provide advisory support.
Rodgers: Bionym is founded on research. The determination and dedication it takes to do that research is a quality that has carried them to where they are today.
What’s been the key to their success, from your perspective?
Scissons: A few things. Their technology was both created and proven effective by world-class researchers at U of T, which gave it credibility. Their timing was also impeccable. Wearable computing is a burgeoning industry and there is a growing interest in it in light of prevalent security issues and data breaches with current state of the art authentication protocols. Their ECG model is a novel approach.
Finally, they had a great team. The founders had the right mix of talent and passion for entrepreneurship. Today the team has continued to grow “organically,” meaning that the roughly 40-person Bionym team continues to find talent primarily from the University of Toronto. They are a great example of entrepreneurs that fully took advantage of the entrepreneurship eco-system here at U of T by engaging with the Innovations & Partnerships Office, the Creative Destruction Lab, Next36 founders and MaRS.
Rodgers: They have been successful at raising capital from great investors and building interest in their product. Those are great first steps towards long-term success. They got there with a positive attitude, a desire to learn and be coached, and a vision on how their research can used by everyone.
What does the Bionym example say to the young companies you’re working with at UTEST and Creative Destruction Lab?
Scissons: This is not an overnight success. The technology was developed for years within the U of T Biometrics Security Laboratory. The team came up against challenges in the early commercialization days but overcame them. Their successful pivot is a strong example for current UTEST companies that may struggle. Karl Martin also continues to give back to the U of T entrepreneurship community, lending his time to speak with and advise current UTEST companies.
Rodgers: At the Lab we use their personal growth in understanding research alone isn’t enough to build a company with; a product mindset is essential. That change in thinking towards product has helped the company grow to where it is now.
Learn more about entrepreneurship at U of T Engineering.
In Canada, we often take safe drinking water and a stable food supply for granted. But in many parts of the world, people are much less fortunate.
Two recently announced Grand Challenges Canada (GCC) grants will allow U of T Engineering researchers to bring their expertise to bear on some of the most urgent global health issues using scientific, technical, social and business innovation.
The grants were included in the latest round of GCC grants, with two previous grants this year given to U of T engineers for new methods that detect defective drugs and a 3D printer that makes skin grafts.
The latest two project teams will receive $112,000 in seed funding to implement their innovative products in the developing world.
Fighting childhood malnutrition one bottle at a time
Breast milk is a complete meal that gives infants all they need to thrive. But millions of women in the developing world must return to work quickly – which means the end of breastfeeding and the start of malnutrition that can have life-long effects for the child.
A new project in Dhaka, Bangladesh, called Mother’s Milk will install hospital-grade breast pumps in factories where women work, along with a simple heating system so that breast milk can be pasteurized on site in as little as 30 seconds. Mothers will be able to safely store the milk to help feed their babies when they are away from home.
“Our goal is to lower the rate of infant malnutrition,” said PhD student Scott Genin (ChemE PhD 1T5), a member of the project team. “As a side benefit, we anticipate that factories with this system will also have lower worker turnover, as this will be an attractive benefit for their workers.”
The design was created through the ‘Interdisciplinary Approach to Global Challenges’ course offered through the Centre for Global Engineering – where the Mother’s Milk project team of Scott Genin, MBA student Puja Madhok (Rotman School of Management), and Master’s students Micaela Collins (Dalla Lana School of Public Health) and Marta Blackwell (Munk School of Global Affairs) first met. The group is led by Professor Joseph Wong (Munk School of Global Affairs) and Dr. Sabrina Rashid (International Centre for Diarrhoeal Disease Research, Bangladesh).
https://www.youtube.com/watch?v=0LM1uBnvRok
Trying to clean up drinking water? Turn to the sun
Yu-Ling Cheng (ChemE), director of U of T’s Centre for Global Engineering, is working with collaborators in Bangladesh to address one of the most serious health issues in the developing world: access to clean drinking water.
In areas like coastal Bangladesh, large parts of the population depend on rainwater that is collected from roofs during the rainy season and stored in cisterns for use during the months-long dry season. Often this rainwater is not very clean to begin with, and nasty pathogens can multiply in the water during the long months of storage, creating an even greater health hazard for millions of people.
Professor Cheng’s team is harnessing the sun’s UV light to improve the quality of the water as it is collected, treat it during storage and then further decontaminate it just before it’s consumed. Called Enhanced Solar Disinfection (eSODIS), the method will use ingenious cistern design and a small “just-in-time” solar-activated disinfection/dispensing module to increase the effectiveness of UV disinfection.
“I am proud of all of the projects that have come out of the Centre for Global Engineering, including the two being funded here by Grand Challenges Canada,” said Cheng. “They are examples of really important problems in the developing world where the skills and expertise of our faculty members and students can be applied to great effect.”
https://www.youtube.com/watch?v=J7p1YJB5LQY
If emerging economies are to prosper and compete in the 21st century, Enrique García, president and CEO of Latin America’s largest development bank, says there are two areas in need of critical attention:
“Education and infrastructure…that is why we are here at the University of Toronto.”
Last Thursday, García and a delegation from CAF — the development bank of Latin America — signed a letter of intent with U of T’s Faculty of Applied Science & Engineering to explore innovative methods for sustainable urban development.
“U of T Engineering is a global leader in transportation, water, energy and infrastructure research for sustainable cities,” said Dean Cristina Amon. “We are excited to collaborate with CAF on developing innovative solutions that will benefit communities in Latin America and around the world.”
CAF is one of the largest sources of financing for infrastructure in South America, providing more funding for projects than the World Bank and the Inter-American Development Bank combined. The organization stresses sustainable growth and regional integration, involving 18 countries in Latin America, the Caribbean and Europe, as well as 14 private banks in the Andean region.
Senior CAF officials, including García and Antonia Juan Sosa, CAF’s vice-president of infrastructure, travelled to U of T last week for a day’s worth of knowledge sharing, research exploration and facility tours.
“Their visit provided an extraordinary opportunity for U of T to showcase our extensive research in sustainable infrastructure and urban development, while learning firsthand about challenges in Latin America,” said Eric Miller, director of the University of Toronto Transportation Research Institute (UTTRI), which hosted the group.
UTTRI will be the focal point for the University’s collaboration with CAF. Launched earlier this year, the Institute is a transportation research hub led by the Faculty of Applied Science & Engineering. It brings together experts from engineering, economics, policy, urban geography and planning, computer science and more from across U of T.
“Our new agreement will leverage UTTRI’s campus-wide research network,” said Miller. “Building on our recent exchange of knowledge and ideas, the next step is to identify an initial set of projects for the two organizations to collaborate on.”
Last Thursday’s visit also involved keynote addresses from García and Sosa to an audience of U of T researchers and Canadian business and government leaders, as well as a panel discussion on Latin American infrastructure with John M. Beck, executive chairman of Aecon Group Inc., Riccardo Cossentino, vice-president of infrastructure investment with SNC-Lavalin Capital, and Martin Doble, global managing director of infrastructure for Hatch.
“The link between research and development is very tight,” said García. “Applied research is a direct vehicle for the advancement of societies and the promotion of its productive capacities.”
CAF has also recently signed with several other major universities, including Harvard, Oxford and the London School of Economics.
With 70,000 undergraduate students – a population that rivals some smaller Canadian cities – the University of Toronto can feel like a colossal institution.
But as several international students affirmed at a recent U of T Engineering Exchange Student Welcome Breakfast, the sheer size of the University is matched by the opportunities it offers.
“U of T…is enormous and gorgeous,” said Paula Pecanha Gonçalves, a Brazilian computer engineering student enrolled at U of T through the Science without Borders program. “It was amazing receiving my letter of acceptance. I started imagining things about the University, and when I came here for the first time, it was more than I expected.”
Each year, hundreds of exchange students like Gonçalves join U of T Engineering for the chance to expand the breadth of their education. In 2014 alone, the Faculty welcomed 57 international exchange and 301 Science without Borders (SwB) students. And year after year, U of T Engineering is the top program choice among SwB applicants.
At the welcome breakfast, Gonçalves said she chose U of T Engineering because of its academic reputation and desirable location. Born and raised in a small town in Brazil, she has found living in Toronto a unique experience because of the city’s diversity. “In every corner of the city you can find a person from a different part of the world…I hope to enjoy everything this city can offer and meet other cultures.”
Whether it’s bringing the world’s best and brightest to U of T Engineering, or sending the best of U of T Engineering into the world, the Faculty maintains its commitment to finding global solutions and earning its place on the world stage. The Faculty also aims to provide visiting students with a memorable experience.
“At U of T Engineering, you have boundless opportunities to learn from and work beside some of the most innovative professors and most talented students from Canada and across the globe,” said Dean Cristina Amon. “I encourage you to take part in our many student organizations, clubs, co-curricular and research activities. These will not only contribute to broaden your horizons, but help you forge lifelong ties with our Faculty.”
Another Science without Borders students, Joao Roberto Cavalcanti de Araujo, visiting from the Federal University of Campina Grande, said he found everything at U of T on a “higher level” than he was used to. When asked why he chose U of T Engineering, Cavalcanti de Araujo said, “I chose to take courses in my field of study that I wouldn’t be able to take in Brazil…I feel like I’ll certainly make use of what I’m learning here in the future.”
While his studies are currently front-of-mind, like many of his peers, while in Canada he hopes to learn how to ice skate, snowboard and “of course, play hockey.”
From winter sports or advanced calculus, no matter what Cavalcanti de Araujo, Gonçalves or other students joining from abroad aim to learn during their time at U of T Engineering – their experience at the University will be marked by collaboration with diverse and talented peers, unprecedented challenges and expert guidance from faculty.
Learn more about U of T Engineering’s newest cohort of undergraduates.